NAcM-OPT
- Product Name
- NAcM-OPT
- CAS No.
- 2089293-61-6
- Chemical Name
- NAcM-OPT
- Synonyms
- NAcM-OPT; NAcM-OPT NEW;Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-;E3 ligating enzyme,Ubiquitin activating enzyme,inhibit,NAcM-OPT,NAE,Ubiquitin conjugating enzyme,NAcMOPT,Ubiquitin ligase,NEDD8-activating Enzyme,E1 activating enzyme,E2 conjugating enzyme,Inhibitor,NAcM OPT,E1/E2/E3 Enzyme
- CBNumber
- CB64668257
- Molecular Formula
- C23H29Cl2N3O
- Formula Weight
- 434.4
- MOL File
- 2089293-61-6.mol
NAcM-OPT Property
- Boiling point:
- 589.8±50.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
- pka
- 13.30±0.70(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year as from date of purchase supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- N633053
- Product name
- NAcM-OPT
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- BN165240
- Product name
- NAcM-OPT NEW
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-0042279
- Product name
- NAcM-OPT
- Purity
- 98.60%
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 2411EJ
- Product name
- NAcM-OPT
- Packaging
- 10mg
- Price
- $164
- Updated
- 2021/12/16
- Product number
- CS-0042279
- Product name
- NAcM-OPT
- Purity
- 98.60%
- Packaging
- 50mg
- Price
- $270
- Updated
- 2021/12/16
NAcM-OPT Chemical Properties,Usage,Production
Description
NAcM-OPT (2089293-61-6) is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1? It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1
Uses
NAcM-OPT inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.
Definition
ChEBI: 1-Benzyl-1-(1-butyl-4-piperidinyl)-3-(3,4-dichlorophenyl)urea is a member of ureas.
References
1) Scott et al. (2017), Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase; Nat. Chem. Biol., 13 850 2) Scott et al. (2011), N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex; Science, 334 674
NAcM-OPT Preparation Products And Raw materials
Raw materials
Preparation Products
NAcM-OPT Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58